Hamptonville is an unincorporated community located in southwestern Yadkin County, North Carolina, United States. Hamptonville is named for Henry Hampton, a colonel in the Revolutionary Army. Hampton set aside land for a town in 1806.As of the United States 2000 Census, the Census-designated place of Hamptonville had a population of 5,901. It is a Piedmont Triad community. The community is primarily rural and agricultural with many residences scattered across the area. Denser residential and business development is centered on Brooks Crossroads, which is generally the hub of the town as it is just north of US 421 at US 21 and Old Hwy 421 and is the primary route for commuters to work in and out of town and to the elementary school.