Hardeeville is a city in Jasper and Beaufort counties in the U.S. state of South Carolina. The population was 4,789 in 2014 based on estimates from the U.S. Census Bureau. Hardeeville is included within the Hilton Head Island-Bluffton-Beaufort, SC Metropolitan Statistical Area.For many years, Hardeeville billed itself as the "Lowcountry Host" due to the prevalence of lodging and traveler-oriented facilities along U.S. Highway 17 and later Interstate 95. In recent years, the city has expanded its economic focus due to high population growth. According to Census estimates, Hardeeville posted the highest population growth rate of any municipality in South Carolina, growing 53.4 percent from 2010 to 2014.